Common Disorders Associated with Fragile X

There are many common disorders which are associated with Fragile X. The most important disorders listed under the sensory symptom category are as follows.


Around one-third of women and most men with Fragile X have some autism-like behaviors. They show similar behavior such as biting themselves, flapping hands, walking on toes, and repetitive actions.

Around 33% of kids with Fragile X may show sufficient amount of autistic behaviors to receive formal diagnosis of autism. But, when people were diagnosed first with autism, only 4% of them had chromosome X with FMR1 gene mutation.

Attention Deficit Hyperactivity Disorder (ADHD) or Attention Deficit Disorder (ADD)

Between 35% to 47% of women and 80% to 90% men with Fragile X may have Attention Deficit Hyperactivity Disorder or Attention Deficit Disorder. These people are unable to pay attention to complete their tasks. They may mess up their work and may be disorganized. Some others may be hyperactive and appear to be in a constant motion.

Connective Tissue Problems

People with Fragile X are also associated with connective tissue problems. Thus, these people who have Fragile X also develop weak connective tissues. Therefore, they have higher risk of developing ear infections and hernias due to dislocation of their joints than those who are unaffected by Fragile X.

Mostly about 50% of adults who have Fragile X may also have heart murmur, which is caused by the mitral valve prolapse. This usually isn’t a life threatening process but they need to consult a medical professional for a regular check-up.


Around 20 percent of kids who have Fragile X may also experience seizures. But, it can be treated with medication and may disappear successfully by adolescence.

Premature Ovarian Failure (POF)

When a woman is aged less than 40, and if her ovaries are not well developed and not working properly then in such cases Premature Ovarian Failure can occur. Around 16% to 19% of women who have a permutation gene with Fragile X may develop POF. Some women who are aged less than 20 years may also have POF. Women who have full mutation gene with Fragile X may be less likely to have POF, but they tend to have menopause earlier than other women who do not carry the mutated gene.

Thus, these are some other disorders that affect every individual who has Fragile X Syndrome. Thus, with some medication and other therapies, they can reduce the effects. This must be done under the guidance of a doctor, as they will be helpful in determining the best treatment.

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